Use of ENCODE resources to characterize novel proteoforms and missing proteins in the human proteome.
作者： Carol L. Nilsson , Ekaterina Mostovenko , Cheryl F. Lichti , Kelly Ruggles , David Fenyö
DOI: 10.1021/PR500564Q
关键词:
摘要: We describe the utility of integrated strategies that employ both translation ENCODE data and major proteomic technology pillars to improve identification "missing proteins", novel proteoforms, PTMs. On one hand, databases in combination with bioinformatic tools are efficiently utilized establish microarray-based transcript analysis supply rapid protein identifications clinical samples. other sequence libraries foundation targeted quantification using mass spectrometric immunoaffinity techniques. The results from combining proteoENCODEdb searches experimental spectral indicate some alternative splicing forms detected at level fact translated proteins. Our provide a step toward directives C-HPP initiative related biomedical research.
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