Integrated Chromosome 19 Transcriptomic and Proteomic Data Sets Derived from Glioma Cancer Stem-Cell Lines
作者： Cheryl F. Lichti , Huiling Liu , Alexander S. Shavkunov , Ekaterina Mostovenko , Erik P. Sulman
DOI: 10.1021/PR400786S
关键词: Computational biology 、 Genetics 、 Cancer stem cell 、 Chromosome 19 、 Human Protein Atlas 、 Transcriptome 、 Glioma 、 Microarray 、 Biology 、 Proteome 、 Chromosome
摘要: One subproject within the global Chromosome 19 Consortium is to define chromosome gene and protein expression in glioma-derived cancer stem cells (GSCs). notoriously linked glioma by 1p/19q codeletions, clinical tests are established detect that specific aberration. GSCs tumor-initiating hypothesized provide a repository of tumors can self-replicate be refractory radiation chemotherapeutic agents developed for treatment tumors. In this pilot study, we performed RNA-Seq, label-free quantitative measurements six GSC lines, targeted transcriptomic analysis using 19-specific microarray an additional lines. The data have been deposited ProteomeXchange with identifier PXD000563. Here present insights into differences expression, including identification proteins listed as having no or low evidence at level Human Protein Atlas, co...
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