Post-exercise oxidative stress and obesity in postmenopausal women: the role of beta3-adrenergic receptor polymorphism.
作者： Felicja Lwow , Katarzyna Dunajska , Urszula Tworowska , Diana Jędrzejuk , Łukasz Łaczmański
DOI: 10.1080/09638280701565110
关键词:
摘要: Aim. Some studies indicate that the Trp64Arg polymorphism in gene encoding β3-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus. The aim present study was to evaluate frequency this its relationship obesity oxidative stress postmenopausal women.Material methods. We performed on 200 women, aged 50–60 years. Estimation anthropometric parameters total body fat, android gynoid fat deposits carried out using dual-energy X-ray absorptiometry. Oxidative estimated by measurement thiobarbituric acid-reactive substances (TBARS) serum. Blood for analysis collected before, directly after 6 h a 30-min physical test cycle ergometer. ADRB3 genotyping polymerase chain reaction.Results. Trp64/Arg64 genotype investigated population 12%, Trp64/Trp64 87%. Arg64/Arg64 pr...
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