Ultrashort-TE MRI longitudinal study and characterization of a chronic model of asthma in mice: inflammation and bronchial remodeling assessment.
作者： Andrea Bianchi , Annaïg Ozier , Olga Ousova , Gérard Raffard , Yannick Crémillieux
DOI: 10.1002/NBM.2975
关键词:
摘要: Asthma is a chronic disease characterized by bronchial hyperresponsiveness (BHR), inflammation and remodeling. The great improvements in 1H MRI ultrashort-TE (UTE) sequences the last decade have allowed lung images with high-resolution good signal-to-noise ratio to be obtained parenchymal tissues. In this article, we present UTE study of model asthma mice aim longitudinally assess main features using fully noninvasive approach. Balb/c (n = 6) were sensitized ovalbumin over period 75 days. control group (n = 3) received normal saline on same days. acquisitions performed days 0, 38 78 inflammatory volumes remodeling (peribronchial signal intensity index, PBSI). Plethysmographic studies 39 79 BHR methacholine enhanced pause (Penh) ratio. average volume measured (15.6 ± 2.4 μL) was increased significantly relative (–0.3 ± 0.7 day 38. larger (34.2 ± 3.1 group. PBSI higher (1.53 ± 0.08) (1.16 ± 0.10), but not After sensitization, asthmatic presented 79. Penh ratios correlated This shows, for first time, that lungs may allow quantification peribronchial eosinophilic airways occlusion mucus murine correlates functional parameters. Copyright © 2013 John Wiley & Sons, Ltd.
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