The Pivotal Role of Airway Smooth Muscle in Asthma Pathophysiology
作者： Annaïg Ozier , Benoit Allard , Imane Bara , Pierre-Olivier Girodet , Thomas Trian
DOI: 10.1155/2011/742710
关键词: Inflammation 、 Pathophysiology of asthma 、 Pathophysiology 、 Contraction (grammar) 、 Asthma 、 Cell 、 Medicine 、 Effector 、 Immunology 、 Proinflammatory cytokine
摘要: Asthma is characterized by the association of airway hyperresponsiveness (AHR), inflammation, and remodelling. The aim present article to review pivotal role smooth muscle (ASM) in pathophysiology asthma. ASM main effector AHR. mechanisms AHR asthma may involve a larger release contractile mediators and/or lower relaxant mediators, an improved cell excitation/contraction coupling, alteration contraction/load coupling. Beyond its function, also involved bronchial inflammation Whereas target inflammatory process, it can display proinflammatory immunomodulatory functions, through synthetic properties expression wide range surface molecules. remodelling represents key feature asthmatic plays promoting complementary structural alterations, particular function.
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researchgate.net 参考文章(259)
Vincent H.J. van der Velden, Anthon R. Hulsmann, Autonomic innervation of human airways: structure, function, and pathophysiology in asthma Neuroimmunomodulation. ,vol. 6, pp. 145- 159 ,(1999) , 10.1159/000026376
Janette K. Burgess, Anita E. Blake, Sarah Boustany, Peter R.A. Johnson, Carol L. Armour, Judith L. Black, Nicholas H. Hunt, J. Margaret Hughes, CD40 and OX40 ligand are increased on stimulated asthmatic airway smooth muscle The Journal of Allergy and Clinical Immunology. ,vol. 115, pp. 302- 308 ,(2005) , 10.1016/J.JACI.2004.11.004
N G Carroll, C Cooke, A L James, Bronchial Blood Vessel Dimensions in Asthma American Journal of Respiratory and Critical Care Medicine. ,vol. 155, pp. 689- 695 ,(1997) , 10.1164/AJRCCM.155.2.9032214
J G Garcia, V Lazar, L I Gilbert-McClain, P J Gallagher, A D Verin, Myosin light chain kinase in endothelium: molecular cloning and regulation. American Journal of Respiratory Cell and Molecular Biology. ,vol. 16, pp. 489- 494 ,(1997) , 10.1165/AJRCMB.16.5.9160829
Michael P. Walsh, Jacquelyn E. Andrea, Bruce G. Allen, Odile Clément-Chomienne, Elizabeth M. Collins, Kathleen G. Morgan, Smooth muscle protein kinase C. Canadian Journal of Physiology and Pharmacology. ,vol. 72, pp. 1392- 1399 ,(1994) , 10.1139/Y94-201
Michael M. Grunstein, Haviva Veler, Xiaoyin Shan, Joshua Larson, Judith S. Grunstein, Sing Chuang, Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle. The Journal of Allergy and Clinical Immunology. ,vol. 116, pp. 94- 101 ,(2005) , 10.1016/J.JACI.2005.03.046
Susan Redline, Ira B. Tager, Robert G. Castile, Scott T. Weiss, Marisa Barr, Frank E. Speizer, Assessment of the Usefulness of Helium-Oxygen Maximal Expiratory Flow Curves in Epidemiologic Studies of Lung Disease in Children American Review of Respiratory Disease. ,vol. 136, pp. 834- 840 ,(1987) , 10.1164/AJRCCM/136.4.834
NICOLA SCICHILONE, SOLBERT PERMUTT, ALKIS TOGIAS, The Lack of the Bronchoprotective and Not the Bronchodilatory Ability of Deep Inspiration Is Associated with Airway Hyperresponsiveness American Journal of Respiratory and Critical Care Medicine. ,vol. 163, pp. 413- 419 ,(2001) , 10.1164/AJRCCM.163.2.2003119
Junaith S. Mohamed, Michael A. Lopez, Aladin M. Boriek, Mechanical Stretch Up-regulates MicroRNA-26a and Induces Human Airway Smooth Muscle Hypertrophy by Suppressing Glycogen Synthase Kinase-3β Journal of Biological Chemistry. ,vol. 285, pp. 29336- 29347 ,(2010) , 10.1074/JBC.M110.101147
Tomoko Fujita, Naoya Ukyo, Toshiyuki Hori, Takashi Uchiyama, Functional characterization of OX40 expressed on human CD8+ T cells. Immunology Letters. ,vol. 106, pp. 27- 33 ,(2006) , 10.1016/J.IMLET.2006.04.001