Differential Effects of the Anticonvulsant Topiramate on Neurobehavioral and Histological Outcomes following Traumatic Brain Injury in Rats

摘要: The efficacy of topiramate, a novel therapeutic agent approved for the treatment seizure disorders, was evaluated in model traumatic brain injury (TBI). Adult male rats were anesthetized (sodium pentobarbital, 60 mg/kg, i.p.), subjected to lateral fluid percussion (n = 60) or sham 47) and randomized receive either topiramate vehicle at 30 min (30 8, 20 32 h postinjury p.o.). In Study A, memory using Morris water maze 48 postinjury, after which tissue regional cerebral edema. B, animals motor function 1, 2, 3, 4 weeks composite neuroscore rotating pole test learning ability weeks. Brains analyzed hemispheric loss hippocampal CA3 cell loss. Topiramate had no effect on posttraumatic edema histologic damage when compared vehicle. At h, improved but not brain-injured animals, while one month it impaired performance animals. significantly neuroscores 1 suggesting potentially beneficial following TBI.