Intranuclear inclusions of meningioma associated with abnormal cytoskeletal protein expression.

摘要: We describe a case of meningothelial meningioma with large number intranuclear inclusions. Morphologically, these are divided into cytoplasmic inclusions and nuclear vacuoles. The inclusion has limiting membrane cell organelles filaments. Inclusions this type generally eosinophilic, like the cytoplasm. However, there many that more eosinophilic than cytoplasm or have ground-glass appearance. Some them may contain fine coarse granules. On other hand, vacuole lacks appears empty. In most type, is faintly basophilic substance in margin. Generally, as immunopositive vimentin, but some reactive. Under electron microscope, abnormal aggregation intermediate filaments recognized It considered strong reaction vimentin immunostaining due to present study distinctly demonstrates localization inclusions, it suggested cytoskeleton participates evolution