Nocturnal hormone profiles in patients with schizophrenia treated with olanzapine.

摘要: Summary Nocturnal hormone profiles were measured in patients with schizophrenia predominantly negative symptoms both under drug-free baseline conditions and after subchronic administration of the atypical antipsychotic olanzapine, aim characterizing its pharmacological properties on neuroendocrine level. The following hormones studied sleep laboratory polysomnographic control: adrenocorticotrophic hormone, cortisol, growth (GH), prolactin, testosterone, melatonin. Blood samples taken at regular time intervals over night, serum concentrations determined. Ten completed study, two them excluded from analysis due to incomplete profiles. dynamics nocturnal secretion similar patterns known healthy subjects. After treatment period about 4 weeks, hypothalamic–pituitary–adrenal axis activity was reduced decreased cortisol plasma levels compared conditions. Olanzapine induced a moderate prolactin elevation. characteristic GH peak around onset, clearly present conditions, markedly treatment. Testosterone melatonin not significantly altered. In conclusion, although interpretation is difficult some cases interference indirect effects olanzapine consequences clinical course underlying schizophrenic disorder, findings are consistent receptor-binding profile where, beside D 2 antagonism, antiserotonergic most important.