Effect of vasoactive intestinal polypeptide infused intrapancreatically on glucagon and insulin secretion
作者： Akio Kaneto , Toshio Kaneko , Hiroshi Kajinuma , Kinori Kosaka
DOI: 10.1016/0026-0495(77)90065-8
关键词:
摘要: Synthetic vasoactive intestinal polypeptide (VIP) was infused at a dose of 50 ng/kg/min for 10 min into the cranial pancreaticoduodenal artery in anesthetized dogs. Both mean blood flow and plasma glucagon concentration vein were significantly enhanced during infusion, indicating great augmentation output. The pancreatic venous insulin not raised, but its output increased again due to increase flow. Plasma femoral augmented, whereas that VIP infusion. Mean arterial glucose levels rose gradually Intrapancreatic pretreatment with propranolol failed exert any significant inhibiting effect upon VIP-induced enhancement glucose, flow, or bihormonal These results suggest origin may regulate function endocrine pancreas this be mediated mainly via β-adrenergic receptor system.
elsevier.com
sci-hub.se 参考文章(20)
Mary E Washko, Eugene W Rice, Determination of glucose by an improved enzymatic procedure. Clinical Chemistry. ,vol. 7, pp. 542- 545 ,(1961) , 10.1093/CLINCHEM/7.5.542
Sami I. Said, Viktor Mutt, Isolation from Porcine‐Intestinal Wall of a Vasoactive Octacosapeptide Related to Secretin and to Glucagon FEBS Journal. ,vol. 28, pp. 199- 204 ,(1972) , 10.1111/J.1432-1033.1972.TB01903.X
D. S. Turner, Lauraine Etheridge, V. Marks, J. C. Brown, V. Mutt, Effectiveness of the intestinal polypeptides, IRP, GIP, VIP and motilin on insulin release in the rat. Diabetologia. ,vol. 10, pp. 459- 463 ,(1974) , 10.1007/BF01221638
SAMI I. SAID, VIKTOR MUTT, Long Acting Vasodilator Peptide from Lung Tissue Nature. ,vol. 224, pp. 699- 700 ,(1969) , 10.1038/224699A0
AKIO KANETO, KINORI KOSAKA, Stimulation of Glucagon Secretion by Oxytocin Endocrinology. ,vol. 87, pp. 439- 444 ,(1970) , 10.1210/ENDO-87-2-439
W. M. Bayliss, E. H. Starling, The mechanism of pancreatic secretion The Journal of Physiology. ,vol. 28, pp. 325- 353 ,(1902) , 10.1113/JPHYSIOL.1902.SP000920
SAMI I. SAID, VIKTOR MUTT, Potent Peripheral and Splanchnic Vasodilator Peptide from Normal Gut Nature. ,vol. 225, pp. 863- 864 ,(1970) , 10.1038/225863A0
S. I. Said, V. Mutt, Polypeptide with Broad Biological Activity: Isolation from Small Intestine Science. ,vol. 169, pp. 1217- 1218 ,(1970) , 10.1126/SCIENCE.169.3951.1217
M. Bodanszky, Y. S. Klausner, S. I. Said, Biological Activities of Synthetic Peptides Corresponding to Fragments of and to the Entire Sequence of the Vasoactive Intestinal Peptide Proceedings of the National Academy of Sciences. ,vol. 70, pp. 382- 384 ,(1973) , 10.1073/PNAS.70.2.382
C. R. Morgan, A. Lazarow, Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats Diabetes. ,vol. 12, pp. 115- 126 ,(1963) , 10.2337/DIAB.12.2.115