Helodermin and islet hormone release in isolated rat pancreas.

作者: Burkhard Göke , Rüdiger Göke , Rüdiger Göke , Hans-Christoph Fehmann , Hans-Christoph Fehmann

DOI: 10.1007/BF02952722

关键词:

摘要: The effect of helodermin (1,10,100 pmol/L), a new member the VIP/ secretin/glucagon peptide family, was investigated in glucose- (10 mmol/L) and arginine- induced insulin, glucagon, somatostatin secretion from isolated perfused rat pancreas. Helodermin stimulated release concentration-dependent manner during first (controls, 100%; 1 pmol/L, 113%, ns; 10 175%,p<0.05; 100 233%,p<0.05) second phases 117%, 210%, p<0.05; 362%,p<0.05). There biphasic glucagon response with an inhibition phase 92%; 63%,p<0.05; 52%,p<0.05%) stimulation 362%, p<0.05). had weak stimulatory effects on pancreatic beta cells maximum at pmol/L (first phase: controls, 96%, 148%,p<0.05; 136%, 104%, 170%,p<0.05; ns).

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