Is helodermin produced by medullary thyroid carcinoma cells and normal C-cells? Immunocytochemical evidence
作者： F. Sundler , J. Christophe , P. Robberecht , N. Yanaihara , C. Yanaihara
DOI: 10.1016/0167-0115(88)90060-2
关键词: Medullary carcinoma 、 Calcitonin 、 Secretin 、 Peptide hormone 、 Internal medicine 、 Immunocytochemistry 、 Thyroid 、 Parafollicular cell 、 Biology 、 Thyroid carcinoma 、 Endocrinology
摘要: Abstract Helodermin is a VIP/secretin-like 35-amino acid peptide originally isolated from the venom of lizard Gila monster. Recently, helodermin-immunoreactive material was demonstrated in mammalian salivary glands, brain and gut. In present study 8 human medullary thyroid carcinomas as well 4 normal glands were examined immunocytochemically for presence helodermin using an antiserum raised against helodermin-(5–35) that does not cross-react with VIP or secretin. Cells displaying helodermin-like immunoreactivity found all tumours except one. On whole cells had same distribution those storing calcitonin, suggesting coexistence two peptides most tumour cells. Also C-cells displayed immunoreactivity. The results suggest chemically related to constituent carcinoma C-cells.
ulb.ac.be
core.ac.uk
elsevier.com
sci-hub.se 参考文章(30)
M I Sabate, L S Stolarsky, J M Polak, S R Bloom, I M Varndell, M A Ghatei, R M Evans, M G Rosenfeld, Regulation of neuroendocrine gene expression by alternative RNA processing. Colocalization of calcitonin and calcitonin gene-related peptide in thyroid C-cells. Journal of Biological Chemistry. ,vol. 260, pp. 2589- 2592 ,(1985) , 10.1016/S0021-9258(18)89396-6
B. Amiranoff, N. Vauclin-Jacques, N. Boige, C. Rouyer-Fessard, M. Laburthe, Interaction of Gila monster venom with VIP receptors in intestinal epithelium of human FEBS Letters. ,vol. 164, pp. 299- 302 ,(1983) , 10.1016/0014-5793(83)80305-6
D S Parker, J P Raufman, T L O'Donohue, M Bledsoe, H Yoshida, J J Pisano, Amino acid sequences of helospectins, new members of the glucagon superfamily, found in Gila monster venom. Journal of Biological Chemistry. ,vol. 259, pp. 11751- 11755 ,(1984) , 10.1016/S0021-9258(20)71275-5
F Sundler, O Ljungberg, L Björklund, J Alumets, R Håkanson, Somatostatin-immunoreactive cells in medullary carcinoma of the thyroid. American Journal of Pathology. ,vol. 88, pp. 381- 386 ,(1977)
Hazard Jb, The C cells (parafollicular cells) of the thyroid gland and medullary thyroid carcinoma. A review. American Journal of Pathology. ,vol. 88, pp. 213- 250 ,(1977)
J. P. Raufman, R. T. Jensen, V. E. Sutliff, J. J. Pisano, J. D. Gardner, Actions of Gila monster venom on dispersed acini from guinea pig pancreas American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 242, ,(1982) , 10.1152/AJPGI.1982.242.5.G470
Yoko Kameda, Hideki Oyama, Masahiko Endoh, Masaharu Horino, Somatostatin immunoreactive C cells in thyroid glands from various mammalia species Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 204, pp. 161- 170 ,(1982) , 10.1002/AR.1092040210
P.H. STEENBERGH, J.W.M. HÖPPENER, J. ZANDBERG, B. A. ROOS, H. S. JANSZ, C.J.M. LIPS, Expression of the Proopiomelanocortin Gene in Human Medullary Thyroid Carcinoma The Journal of Clinical Endocrinology and Metabolism. ,vol. 58, pp. 904- 908 ,(1984) , 10.1210/JCEM-58-5-904
A. G. E. Pearse, Julia M. Polak, Bifunctional reagents as vapour- and liquid-phase fixatives for immunohistochemistry. Histochemical Journal. ,vol. 7, pp. 179- 186 ,(1975) , 10.1007/BF01004561
Philipp U. Heitz, Günter Klöppel, Julia M. Polak, Jean-Jacques Staub, Ectopic hormone production by endocrine tumors: Localization of hormones at the cellular level by immunocytochemistry Cancer. ,vol. 48, pp. 2029- 2037 ,(1981) , 10.1002/1097-0142(19811101)48:9<2029::AID-CNCR2820480920>3.0.CO;2-N