Myasthenia gravis and risks for comorbidity

摘要: Myasthenia gravis (MG) is an autoimmune disorder leading to skeletal muscle weakness and fatigability. MG subgroups are defined according pathogenetic autoantibody (against acetylcholine receptor, muscle-specific tyrosine kinase or lipoprotein receptor-related protein 4), thymus pathology clinical manifestations. patients have increased risk for concordant disease, in particular with early onset MG. Most common comorbidities thyroid systemic lupus erythematosus rheumatoid arthritis. Cardiomyositis subclinical heart dysfunction been described thymoma late but represent no major threat. A thymic lymphoepithelioma implies another cancer. Autoimmune represents distinct cancer factor, although lymphomas a few other types reported slightly frequency. Severe MG-related means respiratory failure tract infection. Drug treatment can lead side-effects. Thymectomy regarded as safe procedure both short long term. Non-MG-related comorbidity diagnostic therapeutic challenge, especially elderly patients. Diagnostic accuracy optimal follow-up necessary identify treat all of coexisting disease