Heterogeneous pathologies associated with dementia in Parkinsonism share a prion-like spreading mechanism.

摘要: Cognitive alterations accompany or follow motor disorders in subjects with Parkinsonism. The canonical phenotype of the Parkinson’s disease Dementia (PD-D) Lewy Body (LBD) includes deficit attention, executive and visuospatial functions, presents often apathy, hallucinations, delusions, excessive daytime sleepiness, sleep disorders. However, clinical expression may overlap other neurodegenerative diseases associated cognitive Thus, while clinicians rely on phenomenological patterns to infer causing impairment, inference is weakened by heterogeneous disease. In addition, recent post-mortem studies seem undermine supposed pathology-phenotype coherence, making it more unreliable diagnosis based symptoms. lack coherence between pathology support speculation about a common mechanism underlying progression While very likely that distinct, specific causal event determines itself, might well patterns. A number observations suggest progressive diseases, which cause share prion-like mechanism. seeding process account for spreading lesion.