Nuclear remodeling as a mechanism for genomic instability in cancer.

摘要: This chapter focuses on the three-dimensional organization of nucleus in normal, early genomically unstable, and tumor cells. A cause–consequence relationship is discussed between nuclear alterations resulting genomic rearrangements. Examples are presented from studies conditional Myc deregulation, experimental tumorigenesis mouse plasmacytoma, remodeling Hodgkin's lymphoma, adult glioblastoma. model proposed for cancer progression multiple myeloma. Current models described, including our altered architecture onset instability.