Antibody-dependent haemolytic activity of human leukaemic cells.

摘要: Antibody-dependent cellular cytotoxicity (ADCC) of human leukaemic blood cells against RBC treated with IgG isoantibody was studied by the 51Cr-release method. ADCC in this particular system is a property normal phagocytic monocytic and myeloid series while lymphocytes are inactive. Well differentiated monocytes from patients acute leukaemia were highly cytotoxic engulfed opsonized RBC. Promyelocytic two promyelocytic phagocytic. Seven low myeloblastic had no or cells. Leukaemic B chronic lymphocytic prolymphocytic lacked properties. It concluded that isoantibody-treated may be tool to distinguish between well poorly series.