Long-term effects of angiotensin-converting enzyme inhibition on the arterial wall of adult spontaneously hypertensive rats

摘要: Abstract The effects of long-term angiotensin-converting enzyme (ACE) inhibitor treatment with perindopril 2 mg/kg/day, by gavage, for 3 months on the mechanical function and structure large arteries were studied in adult spontaneously hypertensive rats established hypertension. Hemodynamic parameters, including instantaneous aortic blood flow pressure, recorded under anesthesia at end period. Systemic arterial compliance was calculated from pressure recordings; passive properties situ localized carotid artery measured. Histologic morphologic parameters media, cross-sectional area thickness, size, density smooth muscle nuclei elastin collagen fibers, measured using an automated image analysis system. ACE significantly decreased mean (−27%, p