A Primer of Primate Pathology: Lesions and Nonlesions

摘要: Nonhuman primates are important laboratory animals for biomedical, pharmacology, and toxicology research. To effectively use as models, their gross histologic anatomy, physiology natural history, well common health problems the source from which primate is obtained, must be known understood by pathologists involved in study design and/or interpretation. The first very lesson "primer" is: there no such thing a generic monkey. Brand names (ie, species subspecies) important. Several taxonomic groups of used research including: prosimians, galagos lemurs; New World monkeys, particularily marmosets; Old especially macaques baboons; chimpanzee, an African ape. Differences between taxa exemplified glucocorticoid resistance monkeys compared to results requirement Vitamin D3 high circulating levels steroids cortisone progesterone. ovarian histology probably relate steroid receptor biology well. There also variations disease manifestations, even among closely related rhesus cynomolgus (cynos). For example type D retrovirus infection accompanied lymphomas cynos, but not rhesus. second this "not test article related" does always mean "normal." Lymphoid nodules bone marrow or salivary gland, background finding macaques, often signal presence retrovirus. Other changes normal anatomic may confusing individuals routinely examining tissues. objective paper familiarize with lesions nonlesions (normal anatomy physiology) that influence confound