Accelerated atheroma in lupus—background

摘要: Observational cohort studies in SLE have led to the description of accelerated atherosclerosis as an important cause mortality and morbidity this disease. The clinical observation coronary artery disease occurring premenopausal females with gave rise concept bimodal pattern. This pattern was confirmed autopsy epidemiological studies. These identified hypercholesterolemia particularly its persistence first three years disease, hypertension, lupus itself risk factors for development these patients. It also became evident that corticosteroid therapy plays role elevation plasma lipids while antimalarials resulted a reduction cholesterol, LDL, VLDL, especially steroid-induced hyperlipidemia. Studies outcomes atherosclerotic (angina, myocardial infarction) shown prevalence 6-12% number cohorts. However, more sensitive investigations including perfusion imaging carotid ultrasound demonstrated 40% patients studied. Further process, immunological factors, may clearly define pathogenesis SLE, help elucidate mechanisms general population.