Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis.
作者： Rebekah L Waikel , Xiao-Jing Wang , Dennis R Roop
关键词:
摘要: Abstract c-Myc overexpression has been associated with several types of human cancers. To study the role of c-myc in epidermal differentiation and carcinogenesis, a transgenic …
nature.com
sci-hub.se 参考文章(49)
L. Barisoni, V. D'Agati, M. Trudel, J. Lanoix, Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. American Journal of Pathology. ,vol. 152, pp. 219- 229 ,(1998)
M. Eilers, S. Schirm, J. M. Bishop, The MYC protein activates transcription of the alpha‐prothymosin gene. The EMBO Journal. ,vol. 10, pp. 133- 141 ,(1991) , 10.1002/J.1460-2075.1991.TB07929.X
Hasan Mukhtar, Skin Cancer: Mechanisms and Human Relevance ,(1994)
Brigid Hogan, Elizabeth Lacy, Frank Costantini, Manipulating the mouse embryo: A laboratory manual ,(1986)
P. J. Hurlin, C. Quéva, P. J. Koskinen, E. Steingrímsson, D. E. Ayer, N. G. Copeland, N. A. Jenkins, R. N. Eisenman, Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. The EMBO Journal. ,vol. 14, pp. 5646- 5659 ,(1995) , 10.1002/J.1460-2075.1995.TB00252.X
J A Rothnagel, T Mehrel, W W Idler, D R Roop, P M Steinert, The gene for mouse epidermal filaggrin precursor. Its partial characterization, expression, and sequence of a repeating filaggrin unit. Journal of Biological Chemistry. ,vol. 262, pp. 15643- 15648 ,(1987) , 10.1016/S0021-9258(18)47775-7
Gregory J. Kato, Chi V. Dang, Function of the c-Myc oncoprotein The FASEB Journal. ,vol. 6, pp. 3065- 3072 ,(1992) , 10.1096/FASEBJ.6.12.1521738
C. A. Schoenenberger, A. C. Andres, B. Groner, M. van der Valk, M. LeMeur, P. Gerlinger, Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. The EMBO Journal. ,vol. 7, pp. 169- 175 ,(1988) , 10.1002/J.1460-2075.1988.TB02797.X
Xiao-Jing Wang, David A. Greenhalgh, Joshua N. Eckhardt, Joseph A. Rothnagel, Dennis R. Roop, Epidermal expression of transforming growth factor-α in transgenic mice: Induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression Molecular Carcinogenesis. ,vol. 10, pp. 15- 22 ,(1994) , 10.1002/MC.2940100104
Joseph A. Coppola, Michael D. Cole, Constitutive c- myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment Nature. ,vol. 320, pp. 760- 763 ,(1986) , 10.1038/320760A0