Deregulated expression of c-Myc depletes epidermal stem cells.
作者： Rebekah L. Waikel , Yasuhiro Kawachi , Patricia A. Waikel , Xiao-Jing Wang , Dennis R. Roop
DOI: 10.1038/88889
关键词:
摘要: … MYC2 mouse of 12 weeks exhibits ulcerated lesions in areas of chronic mechanical stress, ie behind the ears (b). Histological analysis of these ulcerated lesions reveals epidermal …
nature.com
sci-hub.se 
researchgate.net 参考文章(25)
Bruno Amati, Hartmut Land, Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death. Current Opinion in Genetics & Development. ,vol. 4, pp. 102- 108 ,(1994) , 10.1016/0959-437X(94)90098-1
Thomas R. Berton, Xiao-Jing Wang, Zhijian Zhou, Christoph Kellendonk, G�nther Sch�tz, Sophia Tsai, Dennis R. Roop, Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains. Genesis. ,vol. 26, pp. 160- 161 ,(2000) , 10.1002/(SICI)1526-968X(200002)26:2<160::AID-GENE20>3.0.CO;2-#
Elisabeth Georges-Labouesse, Nadia Messaddeq, Ghassan Yehia, Laurence Cadalbert, Andrée Dierich, Marianne Le Meur, Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice Nature Genetics. ,vol. 13, pp. 370- 373 ,(1996) , 10.1038/NG0796-370
Tong-Chuan He, Andrew B Sparks, Carlo Rago, Heiko Hermeking, Leigh Zawel, Luis T Da Costa, Patrice J Morin, Bert Vogelstein, Kenneth W Kinzler, None, Identification of c-MYC as a Target of the APC Pathway Science. ,vol. 281, pp. 1509- 1512 ,(1998) , 10.1126/SCIENCE.281.5382.1509
S. Biro, Y. M. Fu, Z. X. Yu, S. E. Epstein, Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 654- 658 ,(1993) , 10.1073/PNAS.90.2.654
Rebekah L Waikel, Xiao-Jing Wang, Dennis R Roop, Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis. Oncogene. ,vol. 18, pp. 4870- 4878 ,(1999) , 10.1038/SJ.ONC.1203040
Philip H. Jones, Fiona M. Watt, Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell. ,vol. 73, pp. 713- 724 ,(1993) , 10.1016/0092-8674(93)90251-K
Richard A.F. Clark, Joan M. Lanigan, Patricia DellaPelle, Eleanor Manseau, Harold F. Dvorak, Robert B. Colvin, Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. Journal of Investigative Dermatology. ,vol. 79, pp. 264- 269 ,(1982) , 10.1111/1523-1747.EP12500075
C. S. Potten, H. E. Wichmann, M. Loeffler, K. Dobek, D. Major, Evidence for discrete cell kinetic subpopulations in mouse epidermis based on mathematical analysis. Cell Proliferation. ,vol. 15, pp. 305- 329 ,(1982) , 10.1111/J.1365-2184.1982.TB01050.X
Fiona M Watt, and Brigid LM Hogan, Out of Eden: Stem Cells and Their Niches Science. ,vol. 287, pp. 1427- 1430 ,(2000) , 10.1126/SCIENCE.287.5457.1427