HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine

摘要: Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription that direct multiple cellular and systemic responses in response to changes oxygen availability. The sensitive signal is generated by a series of iron 2-oxoglutarate-dependent dioxygenases catalyze post-translational hydroxylation specific prolyl asparaginyl residues HIFα subunits thereby promote their destruction inactivation the presence oxygen. In hypoxia, these processes suppressed allowing HIF activate massive transcriptional cascade. Elucidation pathways has opened several new fields cardiovascular research. Here, we review role hydroxylase cardiac development control. We also consider current status, opportunities, challenges therapeutic modulation hydroxylases therapy disease.