Evolutionary engineering of Saccharomyces cerevisiae for improved industrially important properties
作者： Z. Petek Çakar , Burcu Turanlı-Yıldız , Ceren Alkım , Ülkü Yılmaz
DOI: 10.1111/J.1567-1364.2011.00775.X
关键词:
摘要: This article reviews evolutionary engineering of Saccharomyces cerevisiae. Following a brief introduction to the 'rational' metabolic approach and its limitations such as extensive genetic information requirement on organism interest, complexity cellular physiological responses, difficulties cloning in industrial strains, is discussed an alternative, inverse strategy. Major applications with S. cerevisiae are then two general categories: (1) substrate utilization product formation (2) stress resistance. Recent developments functional genomics methods allow rapid identification molecular basis desired phenotypes obtained by engineering. To conclude, when used alone or combination rational and/or computational study analyze processes adaptive evolution, powerful strategy for improvement industrially important, complex properties
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