DNA Adduct Profiles in Hamster Kidney Following Chronic Exposure to Various Carcinogenic and Noncarcinogenic Estrogens
作者： Richard P. DiAugustine , Michael Walker , Sara Antonia Li , Jonathan J. Li
DOI: 10.1007/978-1-4613-9208-8_40
关键词:
摘要: The generation of specific estrogen-induced DNA adduct modifications in the hamster kidney following chronic exposure has been reported. Moreover, these covalent alterations produced by estrogens have suggested to play a critical role renal tumorigenesis this species. Employing P-1 nuclease postlabeling methods, we studied various strongly carcinogenic (Ethinylestradiol, EE) and noncarcinogenic (17α-estradiol, β-dienestrol, indanestrol) compared data untreated or cholesterol-treated castrated male hamsters at 5.0 7.0 months. No significant differences were found between profiles (∼ 10 spots) control groups those generated from any estrogenic compounds tested, whether not. These coupled with very poor metabolism Moxestrol (1lβ-methoxy seen weaken view for alterations, which appears evidently indigenous, neoplastic transformation kidney.
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