Estrogen-Induced Progesterone Receptor in the Syrian Hamster Kidney. IL Modulation by Synthetic Progestins

作者: JONATHAN J. LI , SARA ANTONIA LI

DOI: 10.1210/ENDO-108-5-1751

关键词: Medroxyprogesterone acetateEndocrinologyInternal medicineEstriolEstrogenChemistryEstroneProgesterone CongenersMegestrol acetateHamsterProgesterone receptor

摘要: The estrogen-induced progesterone receptor in the untransformed hamster kidney has been further characterized. ability of various estrogenic hormones to induce specific renal was 17β-estradiol = estrone > estriol 17α-estradiol. At period maximum induction by either diethylstilbestrol (DES) or 17β-estradiol, hormone withdrawal resulted a linear decline content nearly castrate levels after 5 weeks. Readministration estrogen these hormonewithdrawn animals elicited significant increase concentration compared only 9 days treatment. In contrast this anamnestic response, elevation does not occur previously untreated DES-primed hamsters until 19–24 Since had no appreciable affect on progesteron...

参考文章(20)
Jan MESTER, Etienne-Emile BAULIEU, Progesterone Receptors in the Chick Oviduct. FEBS Journal. ,vol. 72, pp. 405- 414 ,(1977) , 10.1111/J.1432-1033.1977.TB11265.X
Robert G. Martin, Bruce N. Ames, A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures Journal of Biological Chemistry. ,vol. 236, pp. 1372- 1379 ,(1961) , 10.1016/S0021-9258(18)64180-8
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
R. L. Bacon, Hadley Kirkman, Malignant Renal Tumors in Male Hamsters (Cricetus auratus) Treated with Estrogen Cancer Research. ,vol. 10, pp. 122- 124 ,(1950)
Terry L. Cuthbertson, Jonathan J. Li, Sara Antonia Li, Nuclear retention of all steroid hormone receptor classes in the hamster renal carcinoma. Cancer Research. ,vol. 39, pp. 2647- 2651 ,(1979)
Sara Antonia Li, Jonathan J. Li, Claude A. Villee, SIGNIFICANCE OF THE PROGESTERONE RECEPTOR IN THE ESTROGEN-INDUCED AND -DEPENDENT RENAL TUMOR OF THE SYRIAN GOLDEN HAMSTER Annals of the New York Academy of Sciences. ,vol. 286, pp. 369- 383 ,(1977) , 10.1111/J.1749-6632.1977.TB29430.X
TERRY R. BROWN, LESLIE BULLOCKS, C. WAYNE BARDIN, In Vitro and In Vivo Binding of Progestins to the Androgen Receptor of Mouse Kidney: Correlation with Biological Activities Endocrinology. ,vol. 105, pp. 1281- 1287 ,(1979) , 10.1210/ENDO-105-6-1281
Wendell W. Leavitt, Tong J. Chen, Thomas C. Allen, J. O'Neal Johnston, REGULATION OF PROGESTERONE RECEPTOR FORMATION BY ESTROGEN ACTION Annals of the New York Academy of Sciences. ,vol. 286, pp. 210- 225 ,(1977) , 10.1111/J.1749-6632.1977.TB29418.X
David T. MacLaughlin, George S. Richardson, Specificity of medroxyprogesterone acetate binding in human endometrium: Interaction with testosterone and progesterone binding sites Journal of Steroid Biochemistry. ,vol. 10, pp. 371- 377 ,(1979) , 10.1016/0022-4731(79)90322-4