作者: JONATHAN J. LI , SARA ANTONIA LI
关键词: Medroxyprogesterone acetate 、 Endocrinology 、 Internal medicine 、 Estriol 、 Estrogen 、 Chemistry 、 Estrone 、 Progesterone Congeners 、 Megestrol acetate 、 Hamster 、 Progesterone receptor
摘要: The estrogen-induced progesterone receptor in the untransformed hamster kidney has been further characterized. ability of various estrogenic hormones to induce specific renal was 17β-estradiol = estrone > estriol 17α-estradiol. At period maximum induction by either diethylstilbestrol (DES) or 17β-estradiol, hormone withdrawal resulted a linear decline content nearly castrate levels after 5 weeks. Readministration estrogen these hormonewithdrawn animals elicited significant increase concentration compared only 9 days treatment. In contrast this anamnestic response, elevation does not occur previously untreated DES-primed hamsters until 19–24 Since had no appreciable affect on progesteron...