Influenza — The Chameleon Virus

摘要: Publisher Summary Human influenza virus was first isolated and identified in the United Kingdom 1933. The prerequisites for work on were discovery of a vital protein virus, hemagglutinin (HA); identification hemagglutinating ability chicken mammalian erythrocytes; and, most importantly, hemagglutination inhibition (HI) test. This chapter focuses HA A virus. serological study animal models postinfection human sera indicated surprising degree antigenic change or drift HA. It emergence completely novel Asia 1957 another 1968 that confirmed suspicion—harbored since Great Spanish Pandemic 1918—that had two epidemiological faces modes, epidemic pandemic. With advent new techniques chemistry electron microscopy, it has become clear is important antigen made up polypeptides—HA1 HA2. These constituents separated studied by peptide mapping, discovered changes occur entirely HAl molecules.