Control of sodium and potassium transport in the cortical collecting duct of the rat. Effects of bradykinin, vasopressin, and deoxycorticosterone.
作者： K Tomita , J J Pisano , M A Knepper
DOI: 10.1172/JCI111935
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摘要: Several factors interact to maintain precise control of electrolyte transport in the mammalian cortical collecting duct. We have studied effects deoxycorticosterone, arginine vasopressin, and bradykinin on net transepithelial sodium potassium isolated, perfused rat ducts. Chronic administration deoxycorticosterone rats increased both absorption secretion above very low basal levels. Consequently, deoxycorticosterone-treated were used for all remaining studies. Arginine vasopressin (10(-10) M bath) caused a sustained fourfold increase threefold secretion. Bradykinin (10(-9) reversible 40-50% inhibition without affecting or potential difference. In perfusate, up 10(-6) had no effect. conclude: As rabbits, chronic increases ducts vitro. causes absorption. peritubular bathing solution reversibly inhibits absorption, possibly by an electroneutral pathway.
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