Curcumin molecular targets in obesity and obesity-related cancers

摘要: Obesity is characterized as an increased BMI, which associated with the risk of several common cancers, including colorectal, breast, endometrial, renal, esophageal, gallbladder, melanoma, multiple myeloma, leukemia, lymphoma and prostate cancer. The obesity-related cancers could be mediated by insulin resistance, adipokines, inflammatory cytokines, sex hormones, transcription factors oxidative stress, disrupt balance between cell proliferation apoptosis. yellowish compound, curcumin (diferuloylmethane), known to possess multifaceted pharmacological effects. molecular mechanisms linking obesity cancer risk, how mediates anticancer activities, have not yet been publicized. Curcumin modulates targets reverses resistance well other symptoms that are cancers. In this study, we show ample evidence exists support recommendations that...