The human gene coding for HCN2, a pacemaker channel of the heart.

摘要: Abstract H yperpolarization-activated, c yclic n ucleotide-gated (HCN) channels, underlying ‘pacemaker’ currents ( I f / h ), are involved in pacemaker activity of cardiac sinoatrial node myocytes and central neurons. Several cDNAs deriving from four different genes were recently identified which code for channels characterized by six transmembrane domains a cyclic nucleotide binding domain. We report here the identification human HCN2 gene show that its functional expression kidney cell line generates current with properties similar to native f-channel heart. The hHCN2 maps telomeric region chromosome 19, band p13.3. This is first genetic locus coding an HCN channel.