Solid state amorphization of pharmaceuticals.

摘要: Amorphous solids are conventionally formed by supercooling liquids or concentrating noncrystallizing solutes (spray-drying and freeze-drying). However, a lot of pharmaceutical processes may also directly convert compounds from crystal to noncrystal which have desired undesired consequences for their stability. The purpose this short review paper is (i) illustrate the possibility amorphize one compound several different routes (supercooling, dehydration hydrate, milling, annealing metastable crystalline forms), (ii) examine factors that favor glass rather than transformations, (iii) discuss role possible amorphous intermediates in solid−solid conversions induced (iv) address issue chemical stability course solid state amorphization, (v) nature obtained nonconventional routes, (vi) show effect milling conditions on glasses properties, (vii) atte...