Targeting peptides for microglia identified via phage display
作者： Tatiana I. Samoylova , Bushra Y. Ahmed , Vitaly Vodyanoy , Nancy E. Morrison , Alexandre M. Samoylov
DOI: 10.1016/S0165-5728(02)00071-1
关键词:
摘要: Abstract Screening with a 7-mer phage display peptide library, panel of cell-targeting peptides for the murine microglial cell line, EOC 20, was recognized. A number similar, but not identical, sets sequences representing more than 75% all line-binding clones were identified. Comparative analysis indicated that motif S / T F X Y W is present in vast majority binding sequences. The selectivity and specificity dominant sequence identified microglia confirmed using both displaying synthetic alone.
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