Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy.

摘要: Reliable early assessment of breast cancer response to neoadjuvant therapy (NAT) would provide considerable benefit patient care and ongoing research efforts, demand for accurate noninvasive early-response biomarkers is likely increase. Response techniques derived from quantitative magnetic resonance imaging (MRI) hold great potential integration into treatment algorithms clinical trials. Quantitative MRI already available assessing include lesion size measurement, dynamic contrast-enhanced MRI, diffusion-weighted proton spectroscopy. Emerging yet promising magnetization transfer chemical exchange saturation elastography, hyperpolarized MR. Translating incorporating these the setting will require close attention statistical validation methods, standardization reproducibility technique, scanning protocol design.