Inhibition of nociception-induced spinal sensitization by anesthetic agents.

摘要: Background: Subcutaneous injection of dilute formalin in the hind paw rat produces a biphasic nociceptive response. Initial C-fiber activity is accompanied by flinching paru for about 5 min (phase I), followed cessation and resumption beginning 15 after lasting 40 or more 2). The second phase depends on changes dorsal horn cell function that occur shortly initial G-fiber discharge. It was previously shown isoflurane, administered during 1, reduced 2 activity, but combination isoflurane nitrous oxide given throughout 1 did not suppress spinal sensitization. same model used to determine effects several inhalation intravenous anesthetic agents test. Methods: test carried out male Sprague-Dawley rats. Animals anesthetized briefly with halothane facilitate injection, were compared animals received MAG anesthesia from before 6 using halothane, enflurane, desflurane, 70% N O, plus halothane. saline immediately either 20 mg/kg thiopental just 10 propofol 3 injection. Flinches/minute counted at thereafter 5-min intervals h. total 1- flinches considered 10-60-min 2. Total between groups one-way analysis variance. Results: I demonstrated significant decrease when controls, while those exhibited no difference. difference whereas activity. Conclusions: Volatile anesthetics significantly sensitization, causes suppression. Thiopental does affect These results may have important implications regarding development postoperative pain