Intracranial ependymomas of childhood: long-term outcome and prognostic factors.

摘要: A detailed outcome analysis was performed on 40 children with intracranial ependymomas treated at our institution between 1975 and 1993 to identify those factors that were predictive of overall progression-free survival. Three patients (7.5%) who in the first 5 years study died within 3 months surgery excluded from further assessments. Eight (22%) 37 survived perioperative period had evidence leptomeningeal dissemination presentation, basis either imaging (three children) and/or cytological (six results. The 5- 10-year survival rates among these 45.1 36.1%, respectively; 57.1 45.0%, respectively. site progression local 17 19 progressive disease. found have a significant association (P < or = 0.05) both univariate multivariate analyses: 1) extent resection, 2) age patient diagnosis, 3) duration symptoms before diagnosis. 5-year survivals 8.9 22%, respectively, residual disease postoperative studies, compared 68 80% no apparent 0.0001 P 0.0001, respectively). Patients younger than fared significantly worse older (5-year 12 versus 60 75% 0.003 0.01, In addition, diagnosis 1 month more protracted course 33 33%, 53 64%, respectively 0.02 for both). Neither finding presentation nor detection anaplastic histological features (e.g., dense cellularity high numbers mitoses) associated this series. combination variables strongest favorable unfavorable outcomes resection extent. Only 2 gross total resections died, whereas 13 20 radiologically incomplete 0.0001).(ABSTRACT TRUNCATED AT 400 WORDS)