Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.

作者: Stephen J Chanock , Laurie Burdett , Meredith Yeager , Victor Llaca , Anita Langerød

DOI: 10.1186/BCR1637

关键词:

摘要: Introduction Genomic alterations have been observed in breast carcinomas that affect the capacity of cells to regulate proliferation, signaling, and metastasis. Re-sequence studies investigated candidate genes based on prior genetic observations (changes copy number or regions instability) other laboratory defined critical somatic mutations such as TP53 PIK3CA.

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