Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor aspirin/NSAID intake.
作者： A.-M. Roucayrol , A. Courillon-Mallet , , C. Charpignon , B. Lesgourgues
DOI: 10.1111/APT.12465
关键词:
摘要: Summary Background The proportion (and even the reality) of peptic ulcer disease (PUD) not related to H. pylori or NSAID/aspirin is debated. Aim To analyse current epidemiological and clinical characteristics in French general hospitals. Methods Prospective multicentre study patients with 32 hospitals over 1 year. status was assessed by histology, and/or serology C13-urea breath test. intake (obtained direct interview) data about concomitant diseases were collected on day endoscopy. Results Nine hundred thirty-three selected during year 2009. After exclusion 118 only erosive duodenitis, 24 major missing data, 13 other causes 65 negative for one test, 713 classified into four groups: 285 (40.0%) had infection; 133 (18.7%) gastrotoxic drugs; 141 (19.8%) both 154 (21.6%) neither infection nor drug (‘idiopathic ulcers’). Patients idiopathic ulcers differed many ways from groups. However, multivariate analysis identified three independent predictors: age, metropolitan origin presence comorbidities. Conclusion In a hospital-based population France, appears fifth cases.
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