Prevalence and risk factors of Helicobacter pylori-negative peptic ulcer: a multicenter study.
作者： Gianmichele Meucci , Roberto Di Battista , Carla Abbiati , Rossella Benassi , Luigi Bierti
DOI: 10.1097/00004836-200007000-00010
关键词:
摘要: Abstract Peptic ulcer disease (PUD) has been described in the absence of Helicobacter pylori (Hp) infection, suggesting that different factors are involved its etiopathogenesis. We investigated prevalence and characteristics Hp-negative (Hp-) PUD an area Northern Italy calculated rate Hp-positive (Hp+) patients with whom Hp might be coincidental not causal. Four hundred nine consecutive endoscopically diagnosed were enrolled seven hospitals. infection was assessed by rapid urease test histologic examination. The attributable risk percentages age groups appropriate formulas. Of 409 patients, 31 (7.6%) Hp− (gastric, 8.3%; duodenal, 7.6%). Age, nonsteriodal antiinflammatory drug (NSAID) consumption, complication rates significantly higher than Hp+ duodenal ulcers (DUs). DU, 58% did use NSAIDs. In percentage for aged 60 years 98%, 88%, 66%, respectively. about 8%, mainly unrelated to any known etiologic factor. one-third over years,
cabdirect.org
sci-hub.st 参考文章(14)
J. C. Thijs, H. P. M. Festen, E. J. Kuipers, The prevalence of Helicobacter pylori in peptic ulcer disease. Alimentary Pharmacology & Therapeutics. ,vol. 9, pp. 59- 69 ,(1995)
Byron Cryeraa, J.Stephen Redfern, Markus Goldschmiedt, Edward Lee, Mark Feldman, Effect of aging on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology. ,vol. 102, pp. 1118- 1123 ,(1992) , 10.1016/0016-5085(92)90746-L
S K Lam, C K Ching, K C Lai, B C Wong, C L Lai, C K Chan, L Ong, Does treatment of Helicobacter pylori with antibiotics alone heal duodenal ulcer? A randomised double blind placebo controlled study. Gut. ,vol. 41, pp. 43- 48 ,(1997) , 10.1136/GUT.41.1.43
BarryJ Marshall, J Robin Warren, ElizabethD Blincow, Michael Phillips, C Stewart Goodwin, Raymond Murray, StephenJ Blackbourn, ThomasE Waters, ChristopherR Sanderson, None, Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. The Lancet. ,vol. 332, pp. 1437- 1442 ,(1988) , 10.1016/S0140-6736(88)90929-4
R. P. H. LOGAN, K. D. BARDHAN, L. R. CELESTIN, A. THEODOSSI, K. R. PALMER, P. I. REED, J. H. BARON, J. J. MISIEWICZ, Eradication of Helicobacter pylori and prevention of recurrence of duodenal ulcer: a randomized, double-blind, multi-centre trial of omeprazole with or without clarithromycin. Alimentary Pharmacology & Therapeutics. ,vol. 9, pp. 417- 423 ,(2007) , 10.1111/J.1365-2036.1995.TB00400.X
R. Pounder, Duodenal ulcers that are difficult to heal. BMJ. ,vol. 297, pp. 1560- 1561 ,(1988) , 10.1136/BMJ.297.6663.1560
Yawer M. Nensey, Timothy T. Schubert, Sante D. Bologna, Chan K. Ma, Helicobacter pylori-negative duodenal ulcer. The American Journal of Medicine. ,vol. 91, pp. 15- 18 ,(1991) , 10.1016/0002-9343(91)90067-8
H. Hyvärinen, S. Salmenkylä, P. Sipponen, Helicobacter pylori-negative duodenal and pyloric ulcer: role of NSAIDs. Digestion. ,vol. 57, pp. 305- 309 ,(1996) , 10.1159/000201350
Ostapowicz N, Borody Tj, Brandl S, Devine M, George Ll, Hyland L, Andrews P, Helicobacter pylori-negative duodenal ulcer. The American Journal of Gastroenterology. ,vol. 86, pp. 1154- 1157 ,(1991)
WL Peterson, AA Ciociola, DL Sykes, DJ McSorley, DD Webb, Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence Alimentary Pharmacology & Therapeutics. ,vol. 10, pp. 251- 261 ,(1996) , 10.1111/J.0953-0673.1996.00251.X