The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010.

摘要: Summary Background Recent data from Western countries indicate that the aetiology of peptic ulcer disease (PUD) is changing as prevalence Helicobacter pylori decreasing while use low-dose aspirin (LDA, ≤325 mg/day) increasing. Aim To investigate and demographics PUD in a well-characterised patient cohort at large tertiary hospital UK between July 2005 June 2010. Methods Patients diagnosed with following endoscopy were categorised non-steroidal anti-inflammatory drug (NSAID)-users or non-users, their H. status determined. Comparisons NSAID-users non-aspirin LDA-users summarised using counts corresponding percentages (for categorical variables) means standard deviations continuous variables). Results Overall, 386 patients enrolled; 57% used NSAIDs (51% LDA only) 43% non-users. whole was pylori-positive (including 66% duodenal ulcers 47% gastric ulcers). Compared older (mean age 68 vs. 61 years) fewer (52% 63%). 71 62 years) more likely to be (61% 41%) than those NSAIDs. Twelve per cent neither nor pylori-positive. Conclusions The NSAIDs, particularly LDA, most commonly associated this cohort. Our findings are compatible decline increase non-NSAID, non-H. previously reported.