Reduced hemoglobin after heart transplantation is no independent risk factor for survival but is associated closely with impaired renal function1

作者: Christian A. Gleissner , Ammanouil Murat , Susanne Sch??fer , Roland Klingenberg , Achim Koch

DOI: 10.1097/01.TP.0000116443.64958.88

关键词:

摘要: BACKGROUND Reduced hemoglobin (Hb) levels after heart transplantation (HTX) are common; however, there only limited data on the association of posttransplant anemia with survival. METHODS In present study, effect Hb determined 7 to 12 months HTX survival was investigated in 156 transplant recipients (129 men and 27 women; age at transplantation, 51.3+/-10.45 years; follow-up, 6.77+/-3.6 years) by univariate multivariate analyses including a broad range clinical demographic patient characteristics. RESULTS Anemia standard definition found 141 (91.6%) patients. According above or below gender-specific median (men, 12.07 g/dL; women, 11.69 g/dL), patients were separated into high- low-Hb group, respectively. Kaplan-Meier analysis demonstrated significantly worse group (P =0.033). Those showed lower body weight, higher serum creatinine levels, calculated clearance; clearance highly significant <0.0001). No differences between groups for age, preoperative cardiac diagnosis, diabetes, azathioprine, steroid angiotensin-converting enzyme inhibitor medication, leukocyte thrombocyte rejection index, cytomegalovirus (CMV) infection serostatus. Multivariate Cox stepwise regression that CMV infection, female donor gender risk factors post-HTX An level was, completely lost as factor =0.44); instead, strong trend reduced could be =0.09). Subsequently, low impaired separate =0.02). CONCLUSIONS Low do not represent an independent survival, but correlation appears primarily caused concomitant functional renal impairment. Further studies will required investigate role sensitive indicator impairment effects treatment long-term

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