Diminished Expression of Sarcoplasmic Reticulum Ca2+-ATPase and Ryanodine Sensitive Ca2+Channel mRNA in Streptozotocin-induced Diabetic Rat Heart
作者： Yasushi Teshima , Naohiko Takahashi , Tetsunori Saikawa , Masahide Hara , Seikoh Yasunaga
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摘要: Abstract Y. Teshima, N. Takahashi, T. Saikawa, M. Hara, S. Yasunaga, Hidaka and Sakata. Diminished Expression of Sarcoplasmic Reticulum Ca2+-ATPase Ryanodine Sensitive Ca2+Channel mRNA in Streptozotocin-induced Diabetic Rat Heart. Journal Molecular Cellular Cardiology (2000) 32, 655–664. The diabetic heart has an abnormal intracellular calcium ([Ca2+]i) metabolism. However, the responsible molecular mechanisms are unclear. present study aimed to investigate mRNAs expressed proteins which regulate [Ca2+]i metabolism streptozotocin (STZ)-induced rats. sarcoplasmic reticulum Ca2+-adenosine triphosphatase (SR Ca2+-ATPase) was significantly less 3 weeks after STZ injection than that age-matched controls. Together with down-regulation SR Ca2+-ATPase, expression ryanodine sensitive Ca2+channel (RYR) also decreased 12 injection. Insulin supplementation fully restored RYR. diminished restoration insulin further confirmed at protein level. In contrast, coding L-type Ca2+channel, Na+-Ca2+exchanger, or phospholamban were not affected These results can be taken indicate RYR is a possible underlying cause cardiac dysfunction STZ-induced
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