A study investigating the acute dose- response effects of 13 mg and 17 mg Δ 9- tetrahydrocannabinol on cognitive-motor skills, subjective and autonomic measures in regular users of marijuana

摘要: Heavy use of marijuana is claimed to damage critical skills related short-term memory, visual scanning and attention. Motor driving safety may be compromised by the acute effects marijuana. The aim this study was investigate 13 mg 17 Delta 9-tetrahydrocannabinol (THC) on important for coordinated movement subjective autonomic measures in regular users Fourteen were enrolled. Each subject tested two separate days. On each test day, subjects smoked low-nicotine cigarettes, one with other without THC. Seventeen THC included cigarette day day. sequence types unknown subject. During smoking, heart rate blood pressure monitored, performed a virtual reality maze task requiring attention motor coordination, followed 3 cognitive tasks (Wisconsin Card Sorting Test (WCST), "gambling" estimation time distance from an approaching car). After smoking THC, hit walls more often than after cigarettes THC; effect not seen patients they Performance WCST affected lesser extent Decision making gambling but m Smoking increased ratings pleasure satisfaction, drug "effect" "high". These findings imply that results impairment cognitive-motor could driving, whereas lower dose appears cause less such