Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset.

摘要: Hypocretin/orexin deficiency appears to be a consistent feature of narcolepsy with putative autoimmune mechanism involved. We treated four hypocretin/orexin-deficient patients intravenous immunoglobulins and assessed the efficacy by repeated polysomnographies questionnaires. Three received treatment within few months after acute onset narcolepsy. A clear improvement in frequency severity cataplexy was obtained benefic effect up 7 without any anticataplectics drugs at follow-up. Our findings point importance early diagnosis narcolepsy, which once quickly may modify its long-term outlook.