Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator.

摘要: The cystic fibrosis transmembrane conductance regulator (CFTR) is essential for epithelial electrolyte transport and has been shown to be a of Na+, K+, Cl− channels. CFTR also enhances osmotic water permeability when activated by cAMP. This was detected initially in Xenopus oocytes present human airway cells, however, the mechanisms remain obscure. Here, we show that activates aquaporin 3 expressed endogenously exogenously laevis. interaction requires stimulation wild type cAMP an intact first nucleotide binding domain as demonstrated other CFTR–protein interactions.