Nuclear localization of beta-catenin in normal and carcinogenic endometrium.
作者： Hideyuki Nei , Tsuyoshi Saito , Hiroshi Yamasaki , Hisanobu Mizumoto , Eiki Ito
DOI: 10.1002/(SICI)1098-2744(199907)25:3<207::AID-MC7>3.0.CO;2-4
关键词:
摘要: We have previously shown that the connexin (Cx) 26 and 32 genes are expressed during secretory phase of human endometrium their expression is downregulated proliferative phase, suggesting a role for intercellular transduction in cell growth control endometrium. To further study possible cell-to-cell interaction regulation, we immunohistochemically analyzed 80 endometrial samples (30 normal endometrium, 20 hyperplasia, 30 cancer) E-cadherin; alpha-, beta-, gamma-catenin; adenomatous polyposis coli (APC) protein, sex-steroid hormone receptors at three points cells: border, cytoplasm, nucleus. In this study, moderate or strong staining beta-catenin nuclei was observed 60.0% hyperplasia 30.0% cancer samples, although gene mutated only two nine showed intensive nuclear staining. Western blotting analysis had intense much higher than did not Furthermore, localization, especially mid- late-proliferative early-secreting phases menstrual cycle. The results suggest localization cancer, as other tumors, implies beta-catenin/Wnt-1 signal highly activated carcinogenesis well physiological conditions.
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