A Cellular MicroRNA, let-7i, Is a Novel Biomarker for Clinical Outcome in Patients With Dilated Cardiomyopathy
作者： Mamoru Satoh , Yoshitaka Minami , Yuji Takahashi , Tsuyoshi Tabuchi , Motoyuki Nakamura
DOI: 10.1016/J.CARDFAIL.2011.07.012
关键词:
摘要: Abstract Background Our previous studies have reported that activation of Toll-like receptor (TLR) 4 is implicated in the etiology human dilated cardiomyopathy (DCM). A recent report has demonstrated let-7i , a member let-7 family cellular microRNAs (miRs) miR-21, miR-126, and miR-155, directly regulate TLR4 expression. The aim this study was to determine whether miR-155 are expressed with DCM, levels related clinical outcomes. Methods Results Endomyocardial biopsy tissues were obtained from 103 patients DCM 37 subjects without left ventricular (LV) dysfunction as control subjects. Levels lower group than controls, whereas miR-21 (both mRNA protein) higher group. negatively correlated protein all After mean follow-up period 509 days, 6 (5.8%) had died due cardiac cause 15 (14.6%) developed heart failure. When divided into tertiles according levels, log-rank analysis showed subgroup low associated poor outcomes ( P = .02). Conclusions decrease may be DCM.
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