Preparation and Evaluation of Self-nanoemulsifying Tablets of Carvedilol
作者： Enas A. Mahmoud , Ehab R. Bendas , Magdy I. Mohamed
DOI: 10.1208/S12249-009-9192-7
关键词:
摘要: The purpose of this study was to combine the advantages self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form emphasizing excipients’ effect on development new form. Systems composed HCO-40, Transcutol® HP, medium-chain triglyceride were prepared. Essential properties prepared regarding carvedilol solubility, model drug, self-emulsification time determined. In order optimize (SNEDDS), formulation dispersion–drug precipitation test performed in absence presence cellulosic polymers. Furthermore, SNEDDS loaded onto liquisolid powders. P-glycoprotein (P-gp) activity selected tested using HCT-116 cells. Carvedilol showed acceptable solubility excipients. It also demonstrated improvement stability upon dilution with aqueous media Use granulated silicon dioxide improved physical powders containing SNEDDS. compressibility marked P-gp inhibition activity. Prepared tablet produced immediate-release forms expected increase bioavailability carvedilol.
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