Alterations in Neurotransmitter Receptor Binding in Discrete Areas of the Copper-Deficient Rat Brain

摘要: Neonatal copper deficiency produced alterations in central neurotransmitter receptors that were selective with respect both to brain region and receptor type. Both high- low-affinity dopamine densities the corpus striatum significantly lowered, 55% 29%, respectively, when expressed on a wet weight basis. There was significant decrease level of muscarinic whether basis (50%) or protein (27%). A smaller reduction density observed cortex, whereas there no effect cerebellum. The treatment did not change beta-adrenergic binding either cortex affinities for ligands affected by low-copper diet. It previously reported produces regionally specific decreases concentrations norepinephrine. greatest occurred concentration striatum. results from studies suggest post-weanling rats may induce morphological lesion.