The dynamics of natural killer cell tolerance

摘要: Natural killer (NK) cells are important mediators of resistance against tumor growth and metastasis. NK cell reactivity is regulated by a balance signals from activating inhibitory receptors. While beneficial, it essential that do not attack normal tissue. The distinction between partly made at the level receptors: transformation often results in induction ligands for such In addition, discriminate self non-self using MHC class I-binding Host I molecules regulate development tolerance, process well understood. Recent data suggest functional maturation may be binary phenomenon: quantitative aspects, with regards to avidity frequency interactions developing cells, generation 'tuned' optimally sensing absence self-MHC I. this article, we discuss models tolerance. Our understanding have significant implications use cancer therapy.