Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information

摘要: The genetic contributions to human common disorders and mouse models of disease are complex often overlapping. In diseases, unlike classical Mendelian disorders, factors generally have small effect sizes, multifactorial, highly pleiotropic. Likewise, pleiotropic overlapping phenotypes. Moreover, phenotypic descriptions in the literature both poorly characterized difficult compare directly. this report, association results from summarized with regard replication, phenotype, gene specific results; organized context a systematic ontology. Similarly within Mammalian Phenotype Human phenotype based sets identified. These then compared individually large groups through dendrogram analysis hierarchical clustering analysis. shown group into phenotypically relevant at coarse fine level on sharing. This provides global perspective genetics as itself disease.