Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.

摘要: Abstract Objective Essential metals play important roles in the carcinogenic process. However, seldom longitudinal investigations have evaluated their lung cancer development. We aimed to investigate associations between multiple essential and incidence explore potential mechanisms. Methods A nested case-control study of 440 incident cases 1:3 frequency matched 1320 healthy controls from Dongfeng-Tongji Cohort was conducted. The baseline plasma concentrations 11 (cobalt, copper, iron, manganese, molybdenum, rubidium, selenium, strontium, stannum, vanadium, zinc) were measured, with estimated. Effect positive metal (zinc) on 4-year telomere attrition then among an occupational cohort 724 workers. also assessed transcriptional regulation effects zinc mRNA expression profiles, expressions zinc-related genes further compared pair-wised tumor normal tissues. Results Elevated level associated lower risk [OR (95% CI) = 0.89 (0.79, 0.99)] decreased [β CI) = −0.73 (−1.27, −0.19)]. These pronounced males. In particularly, could regulate 8 cancer-related genes, including SOD1 , APE TP53BP1 WDR33 LAPTM4B TRIT1 HUWE1 ZNF813 which over-expressed Conclusions propose that high prevent cancer, probably by slowing down regulating genes. results provided a new insight into prevention.