Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 2.

摘要: Changes in pharmacokinetics and pharmacodynamics which occur with aging are reviewed. In Part 1, age-related alterations pharmacokinetics, deals absorption, distribution, metabolism elimination of drugs, summarized. Special emphasis is placed on "drug clearance" conceptual importance for the evaluation drug has only been recently recognized. Age-related physiological their influence major determinants each organ clearance discussed.